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Citation: Zgaya R, Abid S, Abdelmoula G, Smida S, Sassi B, Khairi H. Ovarian Yolk Sac Tumor: Report of two cases.Jr.med.res.2022;5(1): 16-17.
Zgaya et al © All rights are reserved. https://doi.org/10.32512/jmr.5.1.2022/16.17
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Images in clinical practice
Zgaya Rym
1
, Abid Skander
1
, Abdelmoula Ghada
1*
, Smida Safa
1
,Sassi Bouguizane
1,2
, Khairi Hedi
1,2
.
Ovarian Yolk Sac Tumor: Report of two cases.
1: Department of obstetrics and gynaecology,
Farhat Hached University hospital
Sousse, Tunisia
2: College of medicine Sousse Tunisia.
* Corresponding author
Correspondence to:
abdelmoula.gh@outlook.com
Publication Data:
Submitted: February 2,2022
Accepted: April 27,2022
Online: June 30,2022
This article was subject to full peer-review.
This is an open access article distributed under the terms
of the Creative Commons Attribution Non-Commercial
License 4.0 (CCBY-NC) allowing sharing and adapting.
Share: copy and redistribute the material in any medium
or format.
Adapt: remix, transform, and build upon the licensed
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the work provided must be properly cited and cannot be
used for commercial purpose.
Case 1
A 14-year-old girl presented with a large palpable pelvic
mass. The ultrasonography and pelvic MRI revealed a
huge ovarian suspicious mass. The patient underwent
left salpingo-oophorectomy and histopathology findings
were consistent with ovarian yolk sac Tumor. Initial
postoperative course was uneventful. Adjuvant cisplatin-
based chemotherapy was indicated. The patient died
from severe sepsis after the first sessions.
Case 2
A 28-year-old female presented with abdominal
distension and pelvic recurrent pain. Ultrasound
and pelvic MRI revealed left huge solid adnexal
mass. A scan-guided biopsy confirmed yolk-sac
ovarian tumor. Intraoperative findings were a
voluminous ovarian of 20 cm adherent to the
sigmoid and small bowel. A monobloc resection
was performed.
The postoperative course was uneventful.
Adjuvant cisplatin-based chemotherapy was
indicated. Currently the patient is in complete
remission at one year follow up.
Ovarian Yolk Sac Tumor: Report of two cases
Citation: Zgaya R, Abid S, Abdelmoula G, Smida S, Sassi B, Khairi H. Ovarian Yolk Sac Tumor: Report of two cases.Jr.med.res.2022;5(1): 16-17.
Zgaya et al © All rights are reserved. Submit your manuscript: www.jmedicalresearch.com
17
Comments
Yolk sac tumor (YST) is a rare malignant tumor accounting for less than 1% of all ovarian malignancies. YST are the
second most common malignant ovarian germ cell tumor (MOGCT). More than two third f cases are diagnosed in
young female patients. Typical clinical presentation is an abdominal painful mass. Ovarian YST is usually large on
presentation. The diameter may reach 50 cm in some cases [1]. Elevated AFP is almost high in YST and maybe useful
for the postoperative remission monitoring. Magnetic resonance imaging is the most accurate radiological investigation.
Despite the high malignancy character, these tumors are curable by complete surgical excision combined with
chemotherapy specially in early diagnosis cases [2]. Adjuvant chemotherapy should be selected to simultaneously
target epithelial ovarian tumors and germ-cell tumors due to the probability of histological association. Platinum-based
chemotherapy is recommended. The overall 5 years survival may reach 90% for treated cases [3].
Conflict of Interest: None
References
[1] Hodroj K, Stevovic A, Attignon V, Ferraioli D, Meeus P, Croce S, et al. Molecular Characterization of Ovarian Yolk Sac Tumor (OYST). Cancers (Basel).
2021 ;13:220.
[2] Xie CL, Peng CR, Yan JX, Wang LX, Zhou P. Ovarian yolk sac tumor in a patient with sexual differentiation disorder: a case description. Quant Imaging
Med Surg. 2021 Jul;11:3360-66.
[3] Jamshidi P, Taxy JB. Educational Case: Yolk Sac (Endodermal Sinus) Tumor of the Ovary. Acad Pathol. 2020;7:2374289520909497.
